MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

Blog Article

Micro-RNAs (miRNAs) control gene expression at the post-transcriptional level and are widely involved in carcinogenesis, playing a role as both oncogenes and tumor suppressors.MiRNAs act as potent therapeutic weapon in cancer, but their potential therapeutic use is limited by the off-target effect due to their nonspecific distribution in normal tissues.The encapsulation of miRNAs in nanostructured nitrile gloves in a bucket carriers allows targeted effects aimed to destroy cancer cells, without affecting healthy tissues.Due to their small size and the optimal surface/size ratio, nanoparticles (NPs) envelop, protect, and release miRNAs, representing a promising strategy in cancer treatment.In the present review, we bempresas.com discuss the latest advances in the field of miRNA-encapsulating NPs in cancer, focusing on colorectal cancer and its metastatic forms, one of the most common malignancies worldwide.